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The continuous hyperglycemia can induce target organ damage (TOD) by increasing the risk of panvascular disease, including microvascular disease (such as diabetic retinopathy, nephropathy and neuropathy), and atherosclerotic macrovascular disease (cardiovascular, cerebrovascular, and other peripheral vascular diseases)

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These unfortunate effects are strongest in the days immediately after injecting the once-weekly medication

HEL and LPO levels were measured using an HEL enzyme-linked immunosorbent assay (ELISA) kit and LPO assay kit (Japan Institute for the Control of Aging, Nikken SEIL Co

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